Plasmalogens play a critical role in cell membranes— providing unique structural attributes, facilitating signaling processes and protecting membrane lipids from oxidation. It has been reported that reduced levels of plasmalogens is correlated with cognition deficit, oxidative stress, and severity of disease.
Studies showed positive therapeutic outcomes with plasmalogen interventions in AD patients. Furthermore, the severity of disease was improved when circulating levels of DHA and plasmalogens were high. This suggests that plasmalogens may act as scavengers to protect cells from oxidative damages and reducing inflammatory response.