{"id":190,"date":"2021-01-05T09:48:27","date_gmt":"2021-01-05T09:48:27","guid":{"rendered":"https:\/\/www.stop-alz.com\/?page_id=190"},"modified":"2025-05-17T12:14:54","modified_gmt":"2025-05-17T12:14:54","slug":"history","status":"publish","type":"page","link":"https:\/\/www.stop-alz.com\/th\/history\/","title":{"rendered":"History"},"content":{"rendered":"
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2016<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Developed a method for measuring ether phospholipids in humanserum<\/strong>
by HPLC-ELSD method<\/strong><\/h4>
Ref:Lipids,51(8),997-1006,2016<\/h6>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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2015<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Started open trials for people with moderate or sevior Alzheimer’s disease\nand other dementia symptoms on January<\/strong><\/h4>\n
Ref: PLos ONE.2016,11:e0150846<\/h6>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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2014<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Started large scale clinical trials for people with mild dementia(called as
Alzheimer’s disease) for scallop derived Plasmalogen on November
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Succeeded in extracting high-purity plasmalogen derived from sallops.
Safety test completed.
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2013<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Prove that Plasmalogen suppresses apoptosis through activation\nof Akt and ERK 1\/2<\/strong><\/h4>\n
Ref: Los ONE 2013,8:e83508<\/h6>\n

Started research on double shellfish to find for the better materials<\/strong><\/h4>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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2012<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Prove that erythrocyte Plasmalogen is reduced in patients with\nAlzheimer’s disease<\/strong><\/h4>\n
Ref: Dement Geriatr Cogn Disord Extra 2:298-303,2012\nPatent pending 2010-001337<\/h6>\n

Started research on double shellfish to find for the better materials<\/strong><\/h4>\n
Ref: Journal of Neuro inflammation 9:197-209,2012<\/h6>\n

Prove that oral administration of Plasmalogen increases erythrocyte\nplasmalogen<\/strong><\/h4>\n
Ref: Lipids in Health and Disease 11:161-167,2012<\/h6>\n

Plasmalogen safety test completed<\/strong><\/h4>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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2009<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Confirmation of safety and improvement effects of Alzheimer’s disease\nin human trial at medical institutions\n<\/strong><\/h4>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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2007<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Successful sophystification of the Plasmalogen detection,\nSimplification method<\/strong><\/h4>\n
Ref:Analytical Biochemistry 370:54-59,2007<\/h6>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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2006<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Discovered high purity plasmalogen extraction method from\nchicken meat<\/strong><\/h4>\n
Patent published 2006-23296 Patent pending 2007-16056<\/h6>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Hall of Fame for Pioneers<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Takehiko Fujino,MD,PhD.<\/strong><\/h3>

Takehiko Fujino,MD,PhD, is an Emeritus Professor of Kyushu University. He graduated from Medical School of Kyushu University, Japan, in 1964. He is strongly interested in the integrated medicine, especially in the correlation between brain and other organs although his specialty was initially cardiology of internal medicine. He advocated a new concept \u201cBrain Fatigue\u201d, from which many kinds of diseases might be induced, and developed \u201cBOOCS: Brain-Oriented Oneself-Care System\u201d, a new method for removal of \u201cBrain Fatigue\u201d in 1991. It has been known that many kinds of disorders such as metabolic syndrome, depression and dementia were improved and then the death rate of those patients decreased by \u201cBOOCS\u201d method. As one of those researches, he has studied the correlation among \u201cBrain Fatigue\u201d, Alzheimer\u2019s disease and plasmalogen.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Shiro Mawatari,MD.PhD.<\/strong><\/h3>\nShiro Mawatari, MD, PhD, is a Director of Institute of Rheological functions of Food. He graduated from Medical School of Kyushu University (Fukuoka, Japan) in 1964, and was engaged in biochemical research on erythrocyte membrane of dystrophy at School of Medicine at the University of Pennsylvania (Philadelphia, USA) and Columbia Neuroscience, Columbia University (New York, USA) for three years and a half. After returning to Japan, he worked as an associate professor at Kyushu Institute of Technology (Fukuoka, Japan) and a professor at Fukuoka Women\u2019s University (Fukuoka, Japan). In recent 15 years, he has been dedicated to developing technology for measurement and extraction, and to developing functional food from raw materials with its technology. \t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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2016 Developed a method for measuring ether phospholipids in humanserumby HPLC-ELSD method Ref:Lipids,51(8),997-1006,2016 2015 Started open trials for people with moderate or sevior Alzheimer’s disease and other dementia symptoms on January Ref: PLos ONE.2016,11:e0150846 2014 Started large scale clinical trials for people with mild dementia(called asAlzheimer’s disease) for scallop derived Plasmalogen on November Succeeded in […]<\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-190","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.stop-alz.com\/th\/wp-json\/wp\/v2\/pages\/190"}],"collection":[{"href":"https:\/\/www.stop-alz.com\/th\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.stop-alz.com\/th\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.stop-alz.com\/th\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.stop-alz.com\/th\/wp-json\/wp\/v2\/comments?post=190"}],"version-history":[{"count":43,"href":"https:\/\/www.stop-alz.com\/th\/wp-json\/wp\/v2\/pages\/190\/revisions"}],"predecessor-version":[{"id":3935,"href":"https:\/\/www.stop-alz.com\/th\/wp-json\/wp\/v2\/pages\/190\/revisions\/3935"}],"wp:attachment":[{"href":"https:\/\/www.stop-alz.com\/th\/wp-json\/wp\/v2\/media?parent=190"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}